3月24日是世界防治结核病日，我国首个自主研发的新型结核病mRNA（信使核糖核酸）疫苗启动临床试验。动物实验显示，该疫苗保护效力较卡介苗提高20倍以上。今年7月，结核菌舌拭子快速检测新技术也将在我国逐步推广。

At present, the only approved BCG vaccine in China can prevent severe tuberculosis in infants and young children, but the protective effect on adolescents and adults is limited. The mRNA vaccine developed by the team of Beijing Chest Hospital and biotechnology company has the advantages of high safety and strong ability to induce specific immune responses. According to Xiao Yu, director of the Bacteriological Immunology Department of the hospital, animal experiments have shown that the protective efficacy of this new vaccine is more than 20 times higher than that of traditional BCG and foreign tuberculosis vaccines.

Xiao Yu said that this tuberculosis vaccine with independent intellectual property rights can provide new vaccination options for people of all ages, and effectively reduce the incidence and infection rate of tuberculosis. "In the next step, the R&D team will systematically study the immunization strategy, immunization mode, route of administration and adaptation symptoms of the vaccine."

Sputum examination remains one of the main diagnostic methods for tuberculosis, but it has limitations. For example, in children, obtaining sputum samples is difficult. The sputum collection process is prone to the generation of infectious aerosols, which pose a risk to the health of other populations. On the 2th, the team of Beijing Chest Hospital released the research on a new technology for rapid detection of tuberculosis bacteria based on tongue swabs. The results showed that compared with sputum examination, the sensitivity and specificity of tongue swab for detecting tuberculosis bacteria were increased to 0.0% and 0.0%, respectively.

“从应用场景看，舌拭子诊断产品成本低、易操作、检测速度快，可用于大范围筛查，实现结核病的早期发现。”逄宇表示，舌拭子也能为无痰或无法提供合格痰标本的患者进行快速诊断。此外，舌拭子采样产生气溶胶少，安全性更高。预计2025年7月，这项新技术将在国内逐步推广，2026年应用于大面积筛查。

Beijing Chest Hospital has also released an artificial intelligence diagnosis model, which can realize remote non-invasive early detection of pulmonary diseases such as pulmonary tuberculosis, and has a sensitivity of up to 80% for the diagnosis of pulmonary tuberculosis. At present, the large model is in the preclinical stage.

Source: Beijing Daily client

Reporter: Chai Rong

[Source: Beijing News Network]